ELIMINATE-AF

EFFICACY AND SAFETY IN NVAF PATIENTS UNDERGOING CATHETER ABLATION IN THE ELIMINATE-AF TRIAL

The incidence of the composite primary endpoint in the main analysis was low in both once-daily LIXIANA^® and well-managed VKA in NVAF patients undergoing catheter ablation. Furthermore, there was no statistically significant difference in the incidence of major bleeding between once-daily LIXIANA^® and well-managed VKA in NVAF patients undergoing catheter ablation.¹

PRIMARY ENDPOINT [COMPOSITE OF ALL-CAUSE DEATH, STROKE, AND MAJOR BLEEDING (ISTH^a)] AND, PRIMARY SAFETY ENDPOINT [MAJOR BLEEDING EVENTS]

a International Society on Thrombosis and Haemostasis.
b Patients taking LIXIANA^® 60 mg as standard dose and those dose-reduced to 30 mg.
c Vitamin K antagonist. Median time-in-therapeutic range (TTR): 73%, 65% for PP, mITT, respectively.
d Per-protocol.
e modified Intent-to-treat.
f From the end of catheter ablation to day 90/end of treatment.
g Hazard ratio.
h Confidence interval.

References:

Hohnloser SH, et al. Eur Heart J 2019; 40 (36):3013–21.

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