EDOSURE: Worldwide Edoxaban Clinical Research Program

Daiichi Sankyo is committed to expanding scientific knowledge about edoxaban, as demonstrated through our research program evaluating its use in a broad range of cardiovascular conditions, patient types and clinical settings in atrial fibrillation (AF) and venous thromboembolism (VTE) designed to further build on the results of the pivotal ENGAGE AF and Hokusai-VTE studies.

The goal of EDOSURE is to generate new clinical and real-world-data regarding the use of edoxaban in AF and VTE populations, providing physicians and patients worldwide with greater treatment assurance.

More than 100,000 patients worldwide are expected to participate in the edoxaban clinical research program, EDOSURE, which is comprised of more than 10 randomized, controlled trials, registries and non-interventional studies, including completed, ongoing and future research.

Edoxaban Studies in EDOSURE

Randomized-controlled Clinical Trials in AF and VTE

Nr.

Name

Clinical setting

Comparator

AF patients

VKA

VTE patients

Enoxaparin-Warfarin

AF patients undergoing electrical cardioversion

Enoxaparin-Warfarin

AF patients undergoing PCI

VKA

AF patients undergoing catheter ablation of AF

VKA

AF patients undergoing transcatheter aortic valve implantation (TAVI)

VKA

80 years or older Japanese AF patients who are ineligible for current OAC therapy

placebo

Patients with cancer and an acute VTE event

Subcutaneous Dalteparin

Global and regional registries and non-interventional studies in AF and VTE

Nr.

Name

Clinical setting

Edoxaban treatment in routine clinical practice in AF

Edoxaban treatment in routine clinical practice in VTE

Edoxaban management in diagnostic and therapeutic procedures in AF/VTE

Prevention of thromboembolic events in European Registry in AF patients

All Nippon AF In Elderly Registry in Japan (in more than 75 years in Japan)

Multicentre prospective registry in VTE patients with cancer

AF: atrial fibrillation, OAC: oral anticoagulant, PCI: Percutaneous Coronary Intervention, TAVI: transcatheter aortic valve implantation, VKA: vitamin K antagonist, VTE: venous thromboembolism

Daiichi Sankyo Europe GmbH (“Daiichi Sankyo”) maintains such parts of this site that are expressly directed to an international audience except the UK, USA and Japan for information, education, and communication. While you are free to browse the site, your access to and use of the site is subject to the following terms and conditions (“Terms and Conditions”) and all applicable laws. By accessing and browsing the site, you accept, without limitation or qualification, the Terms and Conditions.

TERMS AND CONDITIONS

The content of this site is NOT INTENDED TO PROVIDE MEDICAL ADVICE, nor meant to be a substitute for advice provided by a physician or other qualified healthcare professional. The information on this site should not be relied on in providing medical advice.

Copyrights and Trademarks

All content of this website, such as text, publications, newsletters, articles, opinions, minutes, notices, views, graphics, images, HTML code, multimedia clips, Java code, and the selection and arrangement of information ("materials") is protected by copyright and other intellectual property laws. All images and text are owned by or licenced to Daiichi Sankyo and, except as provided within these Terms and Conditions, may not be downloaded, distributed, stored, reused, reposted, modified, or otherwise used without the express written permission of Daiichi Sankyo. Daiichi Sankyo neither warrants nor represents that your use of material displayed on the site will not infringe rights of third parties.

Non-commercial Use

You may print a single copy of the content for your own personal, non-commercial use, provided you also retain all copyright and other proprietary notices contained in the materials or as specified on the site. Except for the images expressly stated to be “Downloadable” on the site (“Expressly Downloadable Images”), the further use, re-use, copying, distribution, redistribution, modification, publication, or re-posting of or to any part of this site (including the text, images, audio, and video) is strictly prohibited and nothing contained on this site should be construed as granting, by implication, estoppel, or otherwise, any licence or right to use any Daiichi Sankyo intellectual property right (including, but not limited to any patent, trademark, trade name, copyright or trade secret). The Expressly Downloadable Images may be used for non-commercial use, provided you also retain all copyright notices.

No offer and No solicitation

No information provided on this website constitutes an offer of solicitation for the purchase or disposal of, trading or any transaction in any Daiichi Sankyo securities or products. Investors must not rely on this information for investment decisions.

The website is neither directed at nor designed for use by children (i.e., anyone under 13 years old). To best protect the privacy of children, we ignore any data collected from a user known to be under 13 years old without the proper permission of his or her legal guardian. If requested, a child’s guardian can view any information provided by the child and have it deleted. While Daiichi Sankyo uses reasonable care to ensure that information is accurate at the time it is added on this site, the contents of this site are provided to you "as is," without warranty of any kind, either expressed or implied, including, but not limited to the implied warranties of merchantability, fitness for a particular purpose, or non-infringement and Daiichi Sankyo makes no representations as to the availability, accuracy, or completeness of the content of this site. Daiichi Sankyo may make changes to these materials at any time, without notice, and makes no commitment to update the information contained herein. Therefore, information which has been accurate when first published may no longer be up to date. Daiichi Sankyo shall not be liable for any damages or injury resulting from your access to, or inability to access, this site or from your reliance on any information at this site, or for any viruses that may infect your computer equipment or other property on account of your access to, use of, or browsing in this site or your downloading of any materials, data, text, images, video or audio from this site.

Links to Other Sites

Our site may provide links or references to other Websites not affiliated with Daiichi Sankyo, as well as e-mail links that were checked prior their inclusion. Daiichi Sankyo is not responsible for the content of such other sites and shall not be liable for any damages or injury arising from your access to such sites. Links to other sites are provided only as a convenience to users of our site. A link does not constitute an affiliation with any site or organisation. A link does not constitute an endorsement by any organisation, or an endorsement of any organisation. Should we learn that such third-party websites contain illegal content, we will immediately remove such links.

Feedback and Suggestions

Daiichi Sankyo welcomes your feedback and suggestions about how to improve this site. Any ideas, suggestions, information, know-how, material, or other content (collectively, "content") received through this site, however, will be deemed to include a royalty-free, perpetual, irrevocable, transferable, worldwide, nonexclusive right and licence for Daiichi Sankyo to adopt, publish, reproduce, disseminate, transmit, distribute, copy, use, modify, create derivative works, display (in whole or part), or act on such content without additional approval or consideration, in any form, media, or technology now known or later developed for the full term of any rights that may exist in such content.

The extensive worldwide Edoxaban Clinical Research Program