EDOSURE: Worldwide Edoxaban Clinical Research Program

Daiichi Sankyo is committed to expanding scientific knowledge about edoxaban, as demonstrated through our research program evaluating its use in a broad range of cardiovascular conditions, patient types and clinical settings in atrial fibrillation (AF) and venous thromboembolism (VTE) designed to further build on the results of the pivotal ENGAGE AF-TIMI 48 and Hokusai-VTE studies.

The goal of EDOSURE is to generate new clinical and real-world-data regarding the use of edoxaban in AF and VTE populations, providing physicians and patients worldwide with greater treatment assurance.

More than 100,000 patients worldwide are expected to participate in the edoxaban clinical research program, EDOSURE, which is comprised of more than 10 randomized, controlled trials, registries and non-interventional studies, including completed, ongoing and future research.

Edoxaban Studies in EDOSURE

RANDOMIZED-CONTROLLED CLINICAL TRIALS IN AF AND VTE

Clinical Setting

First Data Disclosure

Non valvular atrial fibrillation patients

Presented at AHA 2013
NCT00781391

VTE patients

Presented at ESC 2013
NCT00986154

AF patients undergoing electrical cardioversion

Presented at ESC 2016
NCT02072434

AF patients undergoing catheter ablation

Presented at EHRA 2019
NCT02942576

AF patients undergoing PCI

Presented at ESC 2019
NCT02866175

AF patients undergoing transcatheter aortic valve implantation

Presented at ESC 2021
NCT02943785

80 years or older Japanese AF patients who are ineligible for current OAC therapy

Presented at ESC 2020
NCT02801669

Patients with VTE associated with cancer

Presented at ASH 2017
NCT02073682

Non valvular AF patients with history of stroke

(Still ongoing)
jRCTs031180249

AF patients with history of intracranial hemorrhage

(Still ongoing)
NCT03950076

REGISTRIES AND NON-RANDOMIZED CLINICAL STUDIES

Edoxaban Treatment in routiNe clinical prActice in Patients with non-valvular Atrial Fibrillation
NCT02944019 (EU) UMIN000017011 (Japan) NCT02951039 (South Korea/Taiwan) NCT03247582 (Hong Kong) NCT03247569 (Thailand)

Prolongation PREFER in AF PREvention oF thromboembolic events-European Registry in Atrial Fibrillation
DRKS00005996

Edoxaban Treatment in routiNe clinical prActice in Patients with Venous ThromboEmbolism
NCT02943993 (EU) UMIN000016387 (Japan) NCT02952599 (South Korea/Taiwan)

All Nippon AF In Elderly registry in Japan to study NVAF in elderly patients aged 75 years and older
UMIN000024006

Edoxaban Management In diagnostic and Therapeutic procedures - AF/VTE
NCT02950168

Venous Thromboembolism (VTE) in Cancer Patients; a Multicenter Prospective Registry in Japan
UMIN000024942

Multicenter study associated with KYU-shu to evaluate the efficacy and safety of edoxaban in patients with non-valvulaR Atrial fiBriLlation undergoing cathEter ablation
UMIN000029693

Real world ablation therapy with anticoagulants in management of atrial fibrillation in Japan
UMIN000026092

Registry of antithrombotic therapy in patients with atrial fibrillation under replacement with bioprosthetic valve in Japan
UMIN000034198 UMIN000034485

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The extensive worldwide Edoxaban Clinical Research Program