Hokusai VTE

EFFICACY AND SAFETY IN PATIENTS WITH CANCER-ASSOCIATED VTE IN THE Hokusai VTE Cancer TRIAL

Once-daily LIXIANA^® was noninferior to subcutaneous Dalteparin with respect to the composite outcome of recurrent venous thromboembolism or major bleeding in patients with cancer-associated VTE.¹

PRIMARY OUTCOME EVENTS OF RECURRENT VENOUS THROMBOEMBOLISM OR MAJOR BLEEDING

a Patients taking LIXIANA^® 60 mg as standard dose and those dose-reduced to 30 mg.
b Hazard ratio.
c Confidence interval.

Once-daily LIXIANA^® was numerically lower in recurrent VTE and higher in major bleeding vs subcutaneous Dalteparin in patients with cancer-associated VTE.¹

CUMULATIVE EVENT RATES FOR SECONDARY OUTCOMES (mITT^e POPULATION OVERALL PERIOD)

RECURRENT VTE^d

a Patients taking LIXIANA^® 60 mg as standard dose and those dose-reduced to 30 mg.
b Hazard ratio.
c Confidence interval.
d Venous thromboembolism.
e modified Intent-to-treat.

MAJOR BLEEDING

a Patients taking LIXIANA^® 60 mg as standard dose and those dose-reduced to 30 mg.
b Hazard ratio.
c Confidence interval.

Major bleeding events predominantly occurred in patients with all types of gastrointestinal cancer in once-daily LIXIANA^® group.²

CUMULATIVE EVENT RATES OF MAJOR BLEEDING IN GASTROINTESTINAL CANCER AND NON-GASTROINTESTINAL CANCER (SAFETY POPULATION ON-TREATMENT PERIOD)

a Patients taking LIXIANA^® 60 mg as standard dose and those dose-reduced to 30 mg.

References:

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